Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50355145 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_772696 (CHEMBL1837164) | ||
IC50 | 77±n/a nM | ||
Citation | Dow, RL; Andrews, M; Aspnes, GE; Balan, G; Michael Gibbs, E; Guzman-Perez, A; Karki, K; Laperle, JL; Li, JC; Litchfield, J; Munchhof, MJ; Perreault, C; Patel, L Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett21:6122-5 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50355145 | |||
n/a | |||
Name | BDBM50355145 | ||
Synonyms: | CHEMBL1833980 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H23N3O4 | ||
Mol. Mass. | 369.4143 | ||
SMILES | Nc1ncnc2OC[C@H](Oc12)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:17.19,wD:20.23,8.12,(9.41,-10.55,;9.42,-12.09,;8.09,-12.86,;8.08,-14.41,;9.42,-15.18,;10.76,-14.41,;12.1,-15.18,;13.44,-14.4,;13.44,-12.85,;12.09,-12.07,;10.75,-12.86,;14.76,-12.08,;16.1,-12.84,;17.43,-12.06,;17.41,-10.51,;16.06,-9.76,;14.74,-10.55,;18.73,-9.73,;18.71,-8.2,;20.04,-7.41,;21.38,-8.17,;22.71,-7.39,;24.05,-8.15,;24.06,-9.69,;25.38,-7.36,;21.39,-9.71,;20.07,-10.49,)| | ||
Structure |