| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Renin |
|---|
| Ligand | BDBM50355536 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_776436 (CHEMBL1913533) |
|---|
| IC50 | 4.4±n/a nM |
|---|
| Citation |  Chen, A; Cauchon, E; Chefson, A; Dolman, S; Ducharme, Y; Dubé, D; Falgueyret, JP; Fournier, PA; Gagné, S; Gallant, M; Grimm, E; Han, Y; Houle, R; Huang, JQ; Hughes, G; Jûteau, H; Lacombe, P; Lauzon, S; Lévesque, JF; Liu, S; Macdonald, D; Mackay, B; McKay, D; Percival, MD; St-Jacques, R; Toulmond, S Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines. Bioorg Med Chem Lett21:3976-81 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Renin |
|---|
| Name: | Renin |
|---|
| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45058.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 406 |
|---|
| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
|
|
|
|---|
| BDBM50355536 |
|---|
| n/a |
|---|
| Name | BDBM50355536 |
|---|
| Synonyms: | CHEMBL1910302 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H40F3N3O4 |
|---|
| Mol. Mass. | 587.6729 |
|---|
| SMILES | COCCCc1ccc(F)c2c(CN(C3CC3)C(=O)[C@H]3CNCC[C@]3(O)c3ccc(F)c(F)c3)cn(CCCOC)c12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
