Reaction Details |
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Target | Muscarinic acetylcholine receptor M4 |
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Ligand | BDBM50355622 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_776587 (CHEMBL1913684) |
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Ki | 0.115±n/a nM |
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Citation | Glossop, PA; Watson, CA; Price, DA; Bunnage, ME; Middleton, DS; Wood, A; James, K; Roberts, D; Strang, RS; Yeadon, M; Perros-Huguet, C; Clarke, NP; Trevethick, MA; Machin, I; Stuart, EF; Evans, SM; Harrison, AC; Fairman, DA; Agoram, B; Burrows, JL; Feeder, N; Fulton, CK; Dillon, BR; Entwistle, DA; Spence, FJ Inhalation by design: novel tertiary amine muscarinic M3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease. J Med Chem54:6888-904 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M4 |
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Name: | Muscarinic acetylcholine receptor M4 |
Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 53079.31 |
Organism: | Homo sapiens (Human) |
Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
Residue: | 479 |
Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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BDBM50355622 |
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n/a |
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Name | BDBM50355622 |
Synonyms: | CHEMBL1910856 |
Type | Small organic molecule |
Emp. Form. | C28H32N2O3 |
Mol. Mass. | 444.5653 |
SMILES | CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(C1)Oc1cccc(O)c1 |
Structure |
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