Reaction Details |
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Target | Muscarinic acetylcholine receptor M1 |
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Ligand | BDBM50296345 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_776583 (CHEMBL1913680) |
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Ki | 0.013±n/a nM |
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Citation | Glossop, PA; Watson, CA; Price, DA; Bunnage, ME; Middleton, DS; Wood, A; James, K; Roberts, D; Strang, RS; Yeadon, M; Perros-Huguet, C; Clarke, NP; Trevethick, MA; Machin, I; Stuart, EF; Evans, SM; Harrison, AC; Fairman, DA; Agoram, B; Burrows, JL; Feeder, N; Fulton, CK; Dillon, BR; Entwistle, DA; Spence, FJ Inhalation by design: novel tertiary amine muscarinic M3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease. J Med Chem54:6888-904 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M1 |
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Name: | Muscarinic acetylcholine receptor M1 |
Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
Type: | Protein |
Mol. Mass.: | 51442.54 |
Organism: | Homo sapiens (Human) |
Description: | P11229 |
Residue: | 460 |
Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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BDBM50296345 |
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n/a |
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Name | BDBM50296345 |
Synonyms: | (1R,2R,4S,5R,7S)-7-(2-hydroxy-2,2-di-thiophen-2-yl-acetoxy)-9,9-dimethyl-3-oxa-9-azonia-tricyclo[3.3.1.0*2,4*]nonane bromide | CHEMBL258622 | Tiotropium Bromide |
Type | Small organic molecule |
Emp. Form. | C19H22NO4S2 |
Mol. Mass. | 392.512 |
SMILES | C[N+]1(C)[C@@H]2C[C@H](C[C@@H]1[C@@H]1O[C@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 |TLB:11:5:1:8.10| |
Structure |
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