Reaction Details |
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Target | Prostaglandin D2 receptor 2 |
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Ligand | BDBM50356669 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_785717 (CHEMBL1920645) |
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IC50 | 81±n/a nM |
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Citation | Crosignani, S; Prêtre, A; Jorand-Lebrun, C; Fraboulet, G; Seenisamy, J; Augustine, JK; Missotten, M; Humbert, Y; Cleva, C; Abla, N; Daff, H; Schott, O; Schneider, M; Burgat-Charvillon, F; Rivron, D; Hamernig, I; Arrighi, JF; Gaudet, M; Zimmerli, SC; Juillard, P; Johnson, Z Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J Med Chem54:7299-317 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin D2 receptor 2 |
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Name: | Prostaglandin D2 receptor 2 |
Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) |
Type: | Enzyme |
Mol. Mass.: | 43295.45 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5Y4 |
Residue: | 395 |
Sequence: | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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BDBM50356669 |
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n/a |
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Name | BDBM50356669 |
Synonyms: | CHEMBL1917584 |
Type | Small organic molecule |
Emp. Form. | C20H19ClO5S |
Mol. Mass. | 406.88 |
SMILES | CCCS(=O)(=O)c1ccc(C)c(c1)C#Cc1cc(Cl)ccc1OCC(O)=O |
Structure |
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