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TargetProstanoid IP receptor
LigandBDBM50351486
Substrate/Competitorn/a
Meas. Tech.ChEMBL_788407
Ki 2700±n/a nM
Citation Iwahashi MNaganawa AKinoshita AShimabukuro ANishiyama TOgawa SMatsunaga YTsukamoto KOkada YMatsumoto RNambu FOumi ROdagaki YKatagi JYano KTani KNakai HToda M Discovery of new orally active prostaglandin D2 receptor antagonists. Bioorg Med Chem 19:6935-48 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostanoid IP receptor
Name:Prostanoid IP receptor
Synonyms:PGI receptor | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40968.22
Organism:Homo sapiens (Human)
Description:The membranes prepared from human platelet were used in binding assay.
Residue:386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
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BDBM50351486
n/a
NameBDBM50351486
Synonyms:CHEMBL1819609
TypeSmall organic molecule
Emp. Form.C25H23ClN2O5
Mol. Mass.466.914
SMILESCN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(O)=O)c3)c(Cl)c2)Oc2ccccc12 |r|
Structure
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