| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
|---|
| Ligand | BDBM50357701 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_785488 (CHEMBL1919967) |
|---|
| IC50 | 2800±n/a nM |
|---|
| Citation |  Andrés, JI; De Angelis, M; Alcázar, J; Iturrino, L; Langlois, X; Dedeurwaerdere, S; Lenaerts, I; Vanhoof, G; Celen, S; Bormans, G Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging. J Med Chem54:5820-35 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent dopamine transporter |
|---|
| Name: | Sodium-dependent dopamine transporter |
|---|
| Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 68497.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q01959 |
|---|
| Residue: | 620 |
|---|
| Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
|
|
|
|---|
| BDBM50357701 |
|---|
| n/a |
|---|
| Name | BDBM50357701 |
|---|
| Synonyms: | CHEMBL1915725 | US9138494, Janssen B-3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H23FN4O |
|---|
| Mol. Mass. | 402.464 |
|---|
| SMILES | Cc1cnc(COc2ccc(cc2)-c2nn(CCF)cc2-c2ccncc2)c(C)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
