Reaction Details | |||
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Target | Mitogen-activated protein kinase 14 | ||
Ligand | BDBM50357910 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_787640 (CHEMBL1918093) | ||
IC50 | 17±n/a nM | ||
Citation | Lumeras, W; Vidal, L; Vidal, B; Balagué, C; Orellana, A; Maldonado, M; Domínguez, M; Segarra, V; Caturla, F 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem54:7899-910 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase 14 | |||
Name: | Mitogen-activated protein kinase 14 | ||
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 41286.76 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q16539 | ||
Residue: | 360 | ||
Sequence: |
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BDBM50357910 | |||
n/a | |||
Name | BDBM50357910 | ||
Synonyms: | CHEMBL1916524 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H22ClF2N3O2 | ||
Mol. Mass. | 493.932 | ||
SMILES | CC(=O)N1CCC(CC1)c1cc(-c2ccccc2Cl)c2cc[n+]([O-])c(-c3c(F)cccc3F)c2n1 |(19.42,-20.86,;18.08,-21.62,;18.07,-23.16,;16.75,-20.84,;15.41,-21.6,;14.08,-20.83,;14.09,-19.29,;15.42,-18.52,;16.76,-19.3,;12.77,-18.52,;12.77,-16.98,;11.43,-16.2,;11.43,-14.66,;12.77,-13.9,;12.77,-12.36,;11.43,-11.59,;10.1,-12.36,;10.1,-13.9,;8.77,-14.67,;10.1,-16.97,;8.76,-16.21,;7.43,-16.98,;7.43,-18.52,;6.1,-19.29,;8.77,-19.29,;8.77,-20.83,;7.43,-21.6,;6.1,-20.83,;7.44,-23.14,;8.77,-23.91,;10.11,-23.12,;10.1,-21.59,;11.43,-20.81,;10.09,-18.52,;11.43,-19.29,)| | ||
Structure |