Reaction Details |
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Target | Calpain-1 catalytic subunit |
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Ligand | BDBM50358133 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_788734 (CHEMBL1924665) |
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IC50 | 27±n/a nM |
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Citation | Stuart, BG; Coxon, JM; Morton, JD; Abell, AD; McDonald, DQ; Aitken, SG; Jones, MA; Bickerstaffe, R Molecular modeling: a search for a calpain inhibitor as a new treatment for cataractogenesis. J Med Chem54:7503-22 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Calpain-1 catalytic subunit |
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Name: | Calpain-1 catalytic subunit |
Synonyms: | CAN1_RAT | Calpain 1 | Capn1 | Cls1 |
Type: | PROTEIN |
Mol. Mass.: | 82108.68 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_788734 |
Residue: | 713 |
Sequence: | MAEELITPVYCTGVSAQVQKQRDKELGLGRHENAIKYLGQDYENLRARCLQNGVLFQDDA
FPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNETILHRVVPYGQSFQEGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHS
AQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILK
ALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTDAKQVTYQGQRVNLIRMRNPWGE
VEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLTPDALKS
RTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEEVDDADDYDSRESGCSFL
LALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPVHLKRDFFLANASRAQSEHFINLR
EVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQELDDQIQANLPDEKVLSEE
EIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDLRTNGFSLESCRSMVNLMDRDG
NGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHELIIT
RYSEPDLAVDFDNFVCCLVRLETMFRFFKILDTDLDGVVTFDLFKWLQLTMFA
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BDBM50358133 |
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n/a |
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Name | BDBM50358133 |
Synonyms: | CHEMBL1923956 |
Type | Small organic molecule |
Emp. Form. | C20H23FN2O4S |
Mol. Mass. | 406.471 |
SMILES | CC(C)[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@@H](Cc1ccccc1)C=O |r| |
Structure |
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