Reaction Details |
| Report a problem with these data |
Target | Metabotropic glutamate receptor 4 |
---|
Ligand | BDBM50358176 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_788858 (CHEMBL1924928) |
---|
EC50 | 201±n/a nM |
---|
Citation | Jones, CK; Engers, DW; Thompson, AD; Field, JR; Blobaum, AL; Lindsley, SR; Zhou, Y; Gogliotti, RD; Jadhav, S; Zamorano, R; Bogenpohl, J; Smith, Y; Morrison, R; Daniels, JS; Weaver, CD; Conn, PJ; Lindsley, CW; Niswender, CM; Hopkins, CR Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkin J Med Chem54:7639-47 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Metabotropic glutamate receptor 4 |
---|
Name: | Metabotropic glutamate receptor 4 |
Synonyms: | GRM4_RAT | Gprc1d | Grm4 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 4 (mGlu4) | Mglur4 | mGlu4 | metabotropic glutamate 4 | metabotropic glutamate 4a |
Type: | Enzyme |
Mol. Mass.: | 101849.79 |
Organism: | Rattus norvegicus (Rat) |
Description: | P31423 |
Residue: | 912 |
Sequence: | MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQ
KSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIA
ATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALAT
KQTYVTYTNHAI
|
|
|
BDBM50358176 |
---|
n/a |
---|
Name | BDBM50358176 |
Synonyms: | CHEMBL1921951 |
Type | Small organic molecule |
Emp. Form. | C16H11N3O5S3 |
Mol. Mass. | 421.471 |
SMILES | O=C(Nc1ccc(cc1)N1S(=O)(=O)c2ccccc2S1(=O)=O)c1nccs1 |
Structure |
|