BindingDB PrimarySearch

Found 238 hits with Last Name = 'smith' and Initial = 'y'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ornithine aminotransferase, mitochondrial (Homo sapiens (Human))	BDBM50121376 (GABACULINE) Show SMILES N[C@@H]1CCCC(=C1)C(O)=O \|r,c:5\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Hebrew University-Hadassah Medical Center Curated by ChEMBL					Assay Description Inhibition of human recombinant OAT using 1 mM alpha-ketoglutarate as substrate				ACS Med Chem Lett 6: 840-4 (2015) Article DOI: 10.1021/acsmedchemlett.5b00153 BindingDB Entry DOI: 10.7270/Q2TQ63B9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Ornithine aminotransferase, mitochondrial (Homo sapiens (Human))	BDBM50199989 ((1S,3S)-3-amino-4-(2,2,2-trifluoro-1-trifluorometh...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Hebrew University-Hadassah Medical Center Curated by ChEMBL					Assay Description Inhibition of human recombinant OAT using 1 mM alpha-ketoglutarate as substrate				ACS Med Chem Lett 6: 840-4 (2015) Article DOI: 10.1021/acsmedchemlett.5b00153 BindingDB Entry DOI: 10.7270/Q2TQ63B9
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50323402 (4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to 5HT7 receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50255538 ((4-(4-(3-chlorobenzyloxy)-3-methylbenzoyl)piperazi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	23.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG channel				Bioorg Med Chem Lett 19: 665-9 (2009) Article DOI: 10.1016/j.bmcl.2008.12.054 BindingDB Entry DOI: 10.7270/Q28C9W3D
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50255483 (4-(3-chloro-4-(3-chlorobenzyloxy)benzoyl)-1-methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	37.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG channel				Bioorg Med Chem Lett 19: 665-9 (2009) Article DOI: 10.1016/j.bmcl.2008.12.054 BindingDB Entry DOI: 10.7270/Q28C9W3D
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50323401 (4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	76	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to adrenergic Alpha-1A receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50255768 (2-(4-chloro-5-(3-chlorobenzyloxy)pyridin-2-yl)-1,3...) Show SMILES Clc1cccc(COc2cnc(cc2Cl)-c2nnco2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG channel				Bioorg Med Chem Lett 19: 665-9 (2009) Article DOI: 10.1016/j.bmcl.2008.12.054 BindingDB Entry DOI: 10.7270/Q28C9W3D
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50255662 (3-chloro-4-(3-chlorobenzyloxy)-N-(4-hydroxybutyl)b...) Show SMILES OCCCCNC(=O)c1ccc(OCc2cccc(Cl)c2)c(Cl)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG channel				Bioorg Med Chem Lett 19: 665-9 (2009) Article DOI: 10.1016/j.bmcl.2008.12.054 BindingDB Entry DOI: 10.7270/Q28C9W3D
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50323402 (4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	103	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to 5HT1A receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50323402 (4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to 5HT2B receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50323402 (4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to 5HT2A receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50323402 (4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to dopamine D2 receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-1 adrenergic receptor (Homo sapiens (Human))	BDBM50323402 (4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to beta-1 adrenergic receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50323402 (4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to dopamine D1 receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50323401 (4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human ERG				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1B adrenergic receptor (Homo sapiens (Human))	BDBM50323401 (4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to adrenergic alpha-1b receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50323401 (4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to 5HT2A receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50323401 (4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to 5HT1A receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50323401 (4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to dopamine D4 receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-2 adrenergic receptor (Homo sapiens (Human))	BDBM50323402 (4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to beta2 adrenergic receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50323401 (4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to dopamine D4 receptor				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Smoothened homolog (Homo sapiens (Human))	BDBM50249488 (4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Smoothened homolog (Homo sapiens (Human))	BDBM50323411 (1-((1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl)me...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of Smoothened transfected in HEK293 cells by binding assay				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50353536 (CHEMBL1830778) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor by cell based assay				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Smoothened homolog (Homo sapiens (Human))	BDBM50323401 (4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Smoothened homolog (Homo sapiens (Human))	BDBM50323406 (1-((5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)met...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of Smoothened transfected in HEK293 cells by binding assay				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50353537 (CHEMBL1830775) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor by cell based assay				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50353537 (CHEMBL1830775) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor by cell based assay				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50278401 (4-(2,6-dimethylphenoxy)-2-(trifluoromethyl)benzoni...) Show SMILES Cc1cccc(C)c1Oc1ccc(C#N)c(c1)C(F)(F)F Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system				Bioorg Med Chem Lett 19: 2176-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.104 BindingDB Entry DOI: 10.7270/Q27P8Z8W
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50353538 (CHEMBL1830944) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human androgen receptor				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50319611 ((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor by cell based assay				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50319611 ((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor by cell based assay				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM25437 ((trifluoromethyl)benzonitrile, 14 \| 4-{[(1R,2S)-2-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity at androgen receptor expressed in MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced response in reporter gen...				Bioorg Med Chem Lett 17: 5983-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.075 BindingDB Entry DOI: 10.7270/Q27W6BWT
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50353539 (CHEMBL1830943) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor by cell based assay				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50221436 (4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity at androgen receptor expressed in MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced response in reporter gen...				Bioorg Med Chem Lett 17: 5983-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.075 BindingDB Entry DOI: 10.7270/Q27W6BWT
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system				Bioorg Med Chem Lett 19: 2176-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.104 BindingDB Entry DOI: 10.7270/Q27P8Z8W
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50353539 (CHEMBL1830943) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human androgen receptor				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50353540 (CHEMBL1830945) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human androgen receptor				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50278353 (4-(2-ethylphenoxy)-2-(trifluoromethyl)benzonitrile...) Show SMILES CCc1ccccc1Oc1ccc(C#N)c(c1)C(F)(F)F Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system				Bioorg Med Chem Lett 19: 2176-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.104 BindingDB Entry DOI: 10.7270/Q27P8Z8W
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Smoothened homolog (Homo sapiens (Human))	BDBM50323405 (1-((1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-y...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of Smoothened transfected in HEK293 cells by binding assay				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50278404 (4-(2-(methylthio)phenoxy)-2-(trifluoromethyl)benzo...) Show SMILES CSc1ccccc1Oc1ccc(C#N)c(c1)C(F)(F)F Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor expressed in human MDA-MB-231 cells assessed as inhibition of DHT-induced response				Bioorg Med Chem Lett 19: 2176-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.104 BindingDB Entry DOI: 10.7270/Q27P8Z8W
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50353541 (CHEMBL1830774) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor by cell based assay				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50353541 (CHEMBL1830774) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor by cell based assay				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Smoothened homolog (Homo sapiens (Human))	BDBM50249488 (4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of Smoothened transfected in HEK293 cells by binding assay				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Androgen receptor (Homo sapiens (Human))	BDBM50319612 ((R)-(+)-4-[4,4-Dimethyl-1-(4-methylsulfanyl-benzyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor by cell based assay				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50319612 ((R)-(+)-4-[4,4-Dimethyl-1-(4-methylsulfanyl-benzyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor by cell based assay				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50319611 ((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human androgen receptor				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50278226 (2-chloro-4-(o-tolyloxy)benzonitrile \| CHEMBL470204) Show SMILES Cc1ccccc1Oc1ccc(C#N)c(Cl)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system				Bioorg Med Chem Lett 19: 2176-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.104 BindingDB Entry DOI: 10.7270/Q27P8Z8W
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50319611 ((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human androgen receptor				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50353540 (CHEMBL1830945) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor by cell based assay				Bioorg Med Chem Lett 21: 5230-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.048 BindingDB Entry DOI: 10.7270/Q21836WZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

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