Ki Summary

Reaction Details

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Target

Metabotropic glutamate receptor 4

Ligand

BDBM50358187

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_788856 (CHEMBL1924926)

EC50

1300±n/a nM

Citation

Jones, CK; Engers, DW; Thompson, AD; Field, JR; Blobaum, AL; Lindsley, SR; Zhou, Y; Gogliotti, RD; Jadhav, S; Zamorano, R; Bogenpohl, J; Smith, Y; Morrison, R; Daniels, JS; Weaver, CD; Conn, PJ; Lindsley, CW; Niswender, CM; Hopkins, CR Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkin J Med Chem54:7639-47 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Metabotropic glutamate receptor 4

Name:

Metabotropic glutamate receptor 4

Synonyms:

Type:

Protein

Mol. Mass.:

101899.95

Organism:

Homo sapiens (Human)

Description:

Q14833

Residue:

912

Sequence:

MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ
KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA
ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT
KQTYVTYTNHAI

BDBM50358187

n/a

Name

BDBM50358187

Synonyms:

CHEMBL1921960

Type

Small organic molecule

Emp. Form.

C20H16ClN3O4

Mol. Mass.

397.812

SMILES

Oc1c2[C@H]3CC[C@H](O3)c2c(O)n1-c1ccc(NC(=O)c2ccccn2)cc1Cl |r,wU:6.6,3.7,(26.11,-24.74,;25.8,-23.23,;26.83,-22.09,;28.36,-22.11,;29.14,-20.79,;28.38,-19.45,;26.86,-19.44,;26.84,-20.97,;26.08,-20.75,;24.57,-21.05,;23.43,-20.01,;24.4,-22.59,;23.08,-23.39,;21.73,-22.64,;20.42,-23.44,;20.44,-24.98,;19.12,-25.77,;17.77,-25.02,;17.75,-23.48,;16.45,-25.81,;16.48,-27.35,;15.16,-28.15,;13.81,-27.4,;13.79,-25.85,;15.11,-25.06,;21.79,-25.73,;23.11,-24.94,;24.46,-25.68,)|

Structure