| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
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| Ligand | BDBM50359814 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_791990 (CHEMBL1930050) |
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| IC50 | 17±n/a nM |
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| Citation |  Reader, JC; Matthews, TP; Klair, S; Cheung, KM; Scanlon, J; Proisy, N; Addison, G; Ellard, J; Piton, N; Taylor, S; Cherry, M; Fisher, M; Boxall, K; Burns, S; Walton, MI; Westwood, IM; Hayes, A; Eve, P; Valenti, M; de Haven Brandon, A; Box, G; van Montfort, RL; Williams, DH; Aherne, GW; Raynaud, FI; Eccles, SA; Garrett, MD; Collins, I Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. J Med Chem54:8328-42 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk1 |
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| Name: | Serine/threonine-protein kinase Chk1 |
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| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54443.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_166295192 |
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| Residue: | 476 |
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| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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| BDBM50359814 |
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| n/a |
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| Name | BDBM50359814 |
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| Synonyms: | CHEMBL1928697 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20N6O |
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| Mol. Mass. | 360.4124 |
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| SMILES | N#Cc1ncc(Nc2cc3ccccc3cn2)nc1OCC1CCNCC1 |
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| Structure | 
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