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Target5-Hydroxytryptamine receptor 6 (5-HT6)
LigandBDBM50361054
Substrate/Competitorn/a
Meas. Tech.ChEMBL_796060
Ki 22.3±n/a nM
Citation Sundar BGBailey TRDunn DDBacon ERSalvino JMMorton GCAimone LDZeqi HMathiasen JRDicamillo AHuffman MJMcKenna BAKopec KLu LDBrown RQian JAngeles TConnors TSpais CHolskin BGalinis DDuzic ESchaffhauser HRosse GC Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists. Bioorg Med Chem Lett 22:120-3 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-Hydroxytryptamine receptor 6 (5-HT6)
Name:Serotonin (5-HT) receptor
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (Human)
Description:Cultured Hela cells expressing h5-HT6 receptors.
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50361054
n/a
NameBDBM50361054
Synonyms:CHEMBL1935600
TypeSmall organic molecule
Emp. Form.C20H18FNO4S
Mol. Mass.387.425
SMILESFc1cccc(c1)S(=O)(=O)c1ccc2c3CCNC4(CCOC4)c3oc2c1
Structure
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