| Reaction Details |
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 | Report a problem with these data |
| Target | Natural resistance-associated macrophage protein 2 |
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| Ligand | BDBM50361126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_795244 (CHEMBL1936903) |
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| IC50 | 410±n/a nM |
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| Citation |  Cadieux, JA; Zhang, Z; Mattice, M; Brownlie-Cutts, A; Fu, J; Ratkay, LG; Kwan, R; Thompson, J; Sanghara, J; Zhong, J; Goldberg, YP Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett22:90-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Natural resistance-associated macrophage protein 2 |
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| Name: | Natural resistance-associated macrophage protein 2 |
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| Synonyms: | DCT1 | DMT-1 | DMT1 | Divalent cation transporter 1 | Divalent metal transporter 1 | NRAM2_HUMAN | NRAMP 2 | NRAMP2 | SLC11A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62262.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_795244 |
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| Residue: | 568 |
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| Sequence: | MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEE
EYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQR
LAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRI
PLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGM
FVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES
CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGG
VVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAI
IPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAG
GILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDC
GHTCHLGLTAQPELYLLNTMDADSLVSR
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| BDBM50361126 |
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| n/a |
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| Name | BDBM50361126 |
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| Synonyms: | CHEMBL1933602 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N4O2 |
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| Mol. Mass. | 308.3345 |
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| SMILES | Cc1[nH]n(-c2ccccn2)c(=O)c1C(=O)Nc1cccc(C)c1 |
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| Structure | 
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