Reaction Details |
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Target | Perforin-1 |
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Ligand | BDBM50361422 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_794525 (CHEMBL1936847) |
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IC50 | 470±n/a nM |
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Citation | Spicer, JA; Huttunen, KM; Miller, CK; Denny, WA; Ciccone, A; Browne, KA; Trapani, JA Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones. Bioorg Med Chem20:1319-36 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Perforin-1 |
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Name: | Perforin-1 |
Synonyms: | PERF_HUMAN | PFP | PRF1 |
Type: | PROTEIN |
Mol. Mass.: | 61392.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1285138 |
Residue: | 555 |
Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
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BDBM50361422 |
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n/a |
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Name | BDBM50361422 |
Synonyms: | CHEMBL1934386 |
Type | Small organic molecule |
Emp. Form. | C21H13N3O3S |
Mol. Mass. | 387.411 |
SMILES | O=C1NC(=S)NC1=Cc1ccc2cc(ccc2n1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| |
Structure |
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