| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50361893 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_799851 (CHEMBL1941557) |
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| EC50 | 4100±n/a nM |
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| Citation |  Pennington, LD; Croghan, MD; Sham, KK; Pickrell, AJ; Harrington, PE; Frohn, MJ; Lanman, BA; Reed, AB; Lee, MR; Xu, H; McElvain, M; Xu, Y; Zhang, X; Fiorino, M; Horner, M; Morrison, HG; Arnett, HA; Fotsch, C; Tasker, AS; Wong, M; Cee, VJ Quinolinone-based agonists of S1P¿?: use of a N-scan SAR strategy to optimize in vitro and in vivo activity. Bioorg Med Chem Lett22:527-31 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42836.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21453 |
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| Residue: | 382 |
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| Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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| BDBM50361893 |
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| n/a |
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| Name | BDBM50361893 |
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| Synonyms: | CHEMBL1938939 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H16F3N3O2 |
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| Mol. Mass. | 423.3872 |
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| SMILES | Cn1cc(C(=O)Nc2ccc(-c3ccccc3)c(c2)C(F)(F)F)c(=O)c2ncccc12 |
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| Structure | 
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