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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase mTOR | ||
| Ligand | BDBM50362916 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_801201 (CHEMBL1949072) | ||
| IC50 | >5000±n/a nM | ||
| Citation |  Mortensen, DS; Perrin-Ninkovic, SM; Harris, R; Lee, BG; Shevlin, G; Hickman, M; Khambatta, G; Bisonette, RR; Fultz, KE; Sankar, S Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors. Bioorg Med Chem Lett21:6793-9 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase mTOR | |||
| Name: | Serine/threonine-protein kinase mTOR | ||
| Synonyms: | FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | FRAP | FRAP 1 (mTOR) | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | Mammalian Target of Rapamycin (mTOR) | P42345 | RAFT1 | RAPT1 | Rapamycin and FKBP12 target 1 | Rapamycin target protein | Serine/threonine-protein kinase (mTOR) | mTORC2 | ||
| Type: | Rapamycin target protein | ||
| Mol. Mass.: | 288917.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P42345 | ||
| Residue: | 2549 | ||
| Sequence: |
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| BDBM50362916 | |||
| n/a | |||
| Name | BDBM50362916 | ||
| Synonyms: | CHEMBL1945794 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H19N5O3 | ||
| Mol. Mass. | 353.3752 | ||
| SMILES | NC(=O)[C@H]1CC[C@@H](CC1)n1c2nc(cnc2[nH]c1=O)-c1ccc(O)cc1 |r,wU:6.9,wD:3.2,(40.89,-22.62,;39.35,-22.64,;38.56,-21.32,;38.6,-23.98,;37.05,-24.01,;36.3,-25.35,;37.1,-26.67,;38.64,-26.65,;39.38,-25.31,;36.35,-28.01,;34.89,-28.5,;33.55,-27.73,;32.24,-28.51,;32.23,-30.05,;33.56,-30.82,;34.89,-30.04,;36.36,-30.51,;37.26,-29.26,;38.8,-29.25,;30.9,-27.74,;29.56,-28.51,;28.23,-27.74,;28.23,-26.2,;26.9,-25.43,;29.56,-25.42,;30.89,-26.19,)| | ||
| Structure | 
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