| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 2 |
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| Ligand | BDBM50363167 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_801406 (CHEMBL1948136) |
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| IC50 | >10000±n/a nM |
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| Citation |  Huber, K; Brault, L; Fedorov, O; Gasser, C; Filippakopoulos, P; Bullock, AN; Fabbro, D; Trappe, J; Schwaller, J; Knapp, S; Bracher, F 7,8-dichloro-1-oxo-ß-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem55:403-13 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 2 |
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| Name: | Serine/threonine-protein kinase PAK 2 |
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| Synonyms: | PAK2 | PAK2_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | Serine/threonine-protein kinase PAK 2 | Serine/threonine-protein kinase PAK 2 (PAK2) | p21-Activated kinase 2 (PAK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 58037.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13177 |
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| Residue: | 524 |
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| Sequence: | MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGT
EKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNP
QAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAP
PVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIV
SIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKE
LKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLH
ANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY
GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRC
LEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR
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| BDBM50363167 |
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| n/a |
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| Name | BDBM50363167 |
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| Synonyms: | CHEMBL1945559 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16Cl2N4O |
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| Mol. Mass. | 363.241 |
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| SMILES | Cn1c2c(C(C#N)C3(CCNCC3)NC2=O)c2ccc(Cl)c(Cl)c12 |
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| Structure | 
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