Reaction Details |
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Target | Serine/threonine-protein kinase Chk2 |
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Ligand | BDBM50363650 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_801825 (CHEMBL1947437) |
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IC50 | 588±n/a nM |
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Citation | Saleem, RS; Lansdell, TA; Tepe, JJ Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors. Bioorg Med Chem20:1475-81 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk2 |
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Name: | Serine/threonine-protein kinase Chk2 |
Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 |
Type: | Protein |
Mol. Mass.: | 60908.59 |
Organism: | Homo sapiens (Human) |
Description: | O96017 |
Residue: | 543 |
Sequence: | MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
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BDBM50363650 |
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n/a |
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Name | BDBM50363650 |
Synonyms: | CHEMBL1947254 |
Type | Small organic molecule |
Emp. Form. | C25H23N5O3 |
Mol. Mass. | 441.4818 |
SMILES | COc1ccc(CNC2=NC(=O)C(N2)=C2CCNC(=O)c3[nH]c(cc23)-c2ccccc2)cc1 |w:14.15,t:8| |
Structure |
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