| Reaction Details |
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 | Report a problem with these data |
| Target | Tissue-type plasminogen activator |
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| Ligand | BDBM50138670 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_801832 (CHEMBL1947444) |
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| IC50 | 125000±n/a nM |
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| Citation |  Venkatraj, M; Messagie, J; Joossens, J; Lambeir, AM; Haemers, A; Van der Veken, P; Augustyns, K Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA). Bioorg Med Chem20:1557-68 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tissue-type plasminogen activator |
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| Name: | Tissue-type plasminogen activator |
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| Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
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| Type: | Enzyme |
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| Mol. Mass.: | 62931.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 562 |
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| Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
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| BDBM50138670 |
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| n/a |
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| Name | BDBM50138670 |
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| Synonyms: | 6-Carbamimidoyl-naphthalene-2-carboxylic acid phenylamide | 6-[(Z)-AMINO(IMINO)METHYL]-N-PHENYL-2-NAPHTHAMIDE | 6-carbamimidoyl-N-phenyl-2-naphthamide | CHEMBL104937 | uPa_7 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15N3O |
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| Mol. Mass. | 289.3312 |
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| SMILES | NC(=N)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1 |
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| Structure | 
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