| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 3 |
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| Ligand | BDBM50364074 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_802348 (CHEMBL1954492) |
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| IC50 | 81300±n/a nM |
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| Citation |  Irvine, MW; Costa, BM; Dlaboga, D; Culley, GR; Hulse, R; Scholefield, CL; Atlason, P; Fang, G; Eaves, R; Morley, R; Mayo-Martin, MB; Amici, M; Bortolotto, ZA; Donaldson, L; Collingridge, GL; Molnár, E; Monaghan, DT; Jane, DE Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors. J Med Chem55:327-41 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, kainate 3 |
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| Name: | Glutamate receptor ionotropic, kainate 3 |
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| Synonyms: | EAA5 | Excitatory amino acid receptor 5 | GLUR7 | GRIK3 | GRIK3_HUMAN | GluR-7 | Glutamate receptor 7 | Glutamate receptor ionotropic kainate | Glutamate receptor ionotropic kainate 3 | Glutamate receptor, ionotropic kainate 3 | Glutamate-Kainate 7 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 104046.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Glutamate-Kainate 7 0 HUMAN::Q13003 |
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| Residue: | 919 |
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| Sequence: | MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMACSTSLAPVFP
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| BDBM50364074 |
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| n/a |
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| Name | BDBM50364074 |
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| Synonyms: | CHEMBL1950805 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17IN2O5 |
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| Mol. Mass. | 504.2746 |
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| SMILES | OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2cc(I)c3ccccc3c2c1 |r| |
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| Structure | 
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