| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily A member 1 |
|---|
| Ligand | BDBM50240419 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_802414 (CHEMBL1954857) |
|---|
| EC50 | 16000±n/a nM |
|---|
| Citation |  Morera, E; De Petrocellis, L; Morera, L; Moriello, AS; Nalli, M; Di Marzo, V; Ortar, G Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. Bioorg Med Chem Lett22:1674-7 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily A member 1 |
|---|
| Name: | Transient receptor potential cation channel subfamily A member 1 |
|---|
| Synonyms: | Anktm1 | TRPA1_RAT | Trpa1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 128622.74 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1450487 |
|---|
| Residue: | 1125 |
|---|
| Sequence: | MKRSLRRVLRPEERKEVQGVVYRGVGKDMDCSKESFKVDIEGDMCRLEAFIKNRRKLSKY
EDENLCLLHHAAAEGQVELMQLIINGSSCEALNVMDDYGNTPLHWAAEKNQVESVKFLLS
QGANPNLRNRNMMAPLHIAVQGMYNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSE
ALQILLEKGAKLCKSNKWGDYPVHQAAFSGAKRCMELILAYGEKTGYSREAHINFVNHKK
ASPLHLAVQSGDLDMIKMCLDSGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSS
DIVNAVDGNQETLLHRASLFDHHDLADYLISVGADINSTDSEGRSPLILATASASWNIVN
LLLSKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFLQMQHIKELVMDEDNDGCTPLHY
ACRQGAPVSVNNLLRFNVSVHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD
LHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLK
CTDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIALHNKRKEVVLTT
IRSKRWDECLQVFTHDSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQDYHIEYN
FKYLQCPLSMTKKVTPTQDVIYEPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFRA
HMMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGIINETISTHEERINTLNSFPLKICMILV
FLSSIFGYCKEVVQIFQQKRNYFLDYNNALEWVIYTTSMIFVLPLFLDIPAYMQWQCGAI
AIFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLLRSTGVFIFLLLAFGLSFYVLLNFQDA
FSTPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLI
GLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPFWYLRKVDQRSTIVYPNRPRHGRMLR
FFHYFLSMQETRQEAPNIDTCLEMEILKQKYRLKDLTSLLEKQHELIKLIIQKMEIISET
EDEDNHCSFQDRFKKERLEQMHSKWNFVLNAVKTKTHCSISHPDI
|
|
|
|---|
| BDBM50240419 |
|---|
| n/a |
|---|
| Name | BDBM50240419 |
|---|
| Synonyms: | (E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one | 6-shogaol | CHEMBL25948 | [(E)-1-(4-hydroxy-3-methoxyphenyl)-dec-4-en-3-one] | [6]-shogaol | trans-6-shogaol |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H24O3 |
|---|
| Mol. Mass. | 276.3707 |
|---|
| SMILES | CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |w:5.4| |
|---|
| Structure | 
|
|---|
Search and Browse
