| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2C19 |
|---|
| Ligand | BDBM50364957 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_804469 (CHEMBL1952479) |
|---|
| IC50 | >30000±n/a nM |
|---|
| Citation |  Hudkins, RL; Zulli, AL; Dandu, Rr; Tao, M; Josef, KA; Aimone, LD; Haltiwanger, RC; Huang, Z; Lyons, JA; Mathiasen, JR; Raddatz, R; Gruner, JA 4-phenoxypiperidine pyridazin-3-one histamine H(3) receptor inverse agonists demonstrating potent and robust wake promoting activity. Bioorg Med Chem Lett22:1504-9 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2C19 |
|---|
| Name: | Cytochrome P450 2C19 |
|---|
| Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55935.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P33261 |
|---|
| Residue: | 490 |
|---|
| Sequence: | MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
|
|
|
|---|
| BDBM50364957 |
|---|
| n/a |
|---|
| Name | BDBM50364957 |
|---|
| Synonyms: | CHEMBL1950643 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23N3O2 |
|---|
| Mol. Mass. | 325.4048 |
|---|
| SMILES | O=c1ccc(n[nH]1)-c1ccc(OC2CCN(CC2)C2CCC2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
