Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Angiopoietin-1 receptor | ||
| Ligand | BDBM50355491 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_806851 (CHEMBL1958979) | ||
| Ki | 200±n/a nM | ||
| Citation |  Heidary, DK; Huang, G; Boucher, D; Ma, J; Forster, C; Grey, R; Xu, J; Arnost, M; Choquette, D; Chen, G; Zhou, JH; Yao, YM; Ball, ED; Namchuk, M; Davies, RJ; Henkel, G VX-322: a novel dual receptor tyrosine kinase inhibitor for the treatment of acute myelogenous leukemia. J Med Chem55:725-34 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Angiopoietin-1 receptor | |||
| Name: | Angiopoietin-1 receptor | ||
| Synonyms: | TEK | TIE2 | TIE2_HUMAN | Tyrosine-protein kinase TIE-2 | Tyrosine-protein kinase receptor (TIE-2) | Tyrosine-protein kinase receptor TEK | Tyrosine-protein kinase receptor TEK (p140 TEK) | Tyrosine-protein kinase receptor TIE-2 | Tyrosine-protein kinase receptor TIE2/TEK | VMCM | VMCM1 | Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2) | p140 TEK | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 125835.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q02763 | ||
| Residue: | 1124 | ||
| Sequence: |
| ||
| BDBM50355491 | |||
| n/a | |||
| Name | BDBM50355491 | ||
| Synonyms: | CHEMBL1835870 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H29N7O | ||
| Mol. Mass. | 419.5227 | ||
| SMILES | Nc1nc(Nc2ccc(cc2)[C@H]2CC[C@@H](CC2)N2CCOCC2)nn1-c1ccccn1 |r,wU:11.11,wD:14.18,(-9.05,.18,;-7.58,.64,;-7.09,2.1,;-5.55,2.08,;-4.8,3.43,;-3.26,3.44,;-2.48,2.12,;-.94,2.14,;-.18,3.48,;-.98,4.81,;-2.52,4.79,;1.35,3.5,;2.1,4.85,;3.65,4.86,;4.44,3.53,;3.68,2.19,;2.14,2.18,;5.97,3.55,;6.75,2.22,;8.29,2.23,;9.05,3.57,;8.27,4.9,;6.73,4.89,;-5.09,.62,;-6.35,-.28,;-6.36,-1.81,;-5.04,-2.59,;-5.05,-4.13,;-6.39,-4.89,;-7.72,-4.11,;-7.71,-2.57,)| | ||
| Structure | 
| ||