Ki Summary

Reaction Details

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Target

Inositol-trisphosphate 3-kinase C

Ligand

BDBM50040911

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_90248

978000±n/a nM

Citation

Liu, C; Safrany, ST; Nahorski, SR; Potter, BV Synthesis of L-chiro-inositol 1,4,6-trisphosphorothioate, a potent and selective inhibitor of myo-inositol 1,4,5-trisphosphate 5-phosphatase Bioorg Med Chem Lett2:1523-1528 (1992) Article

More Info.:

Get all data from this article, Assay Method

Inositol-trisphosphate 3-kinase C

Name:

Inositol-trisphosphate 3-kinase C

Synonyms:

IP3KC_RAT | Inositol 1,4,5-trisphosphate 3 kinase C | Ip3kc | Itpkc

Type:

PROTEIN

Mol. Mass.:

74440.10

Organism:

Rattus norvegicus

Description:

ChEMBL_90248

Residue:

678

Sequence:

MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGPGAGGPTGRPEGGGPRA
WIEGFSLHSEAERTDFGPAPCPDGPQAEPCGDEHEECEAAGLGVASEKPSQNKELDGSNL
QTHPKLSSPLAEMEMAGSWTDGFRTDLHRPDLQARPKRASLCTQPGFDESWTELDRSELW
QTLPERDKPWVDHLRTHQDMSRLQNHPACPSPEPSAGTSCKELSADGSRTPHDTDGFWIE
SQTDGSLIGPSTQTACRQPANDGFSAQDTDGTLIQPGTDDGPWVDSVLEKSNGDDPLMEP
EPRDLVTNLCSHLECSSLCPVPRLIITSESPEPGAQPLGPQARIEGGTGGFSSASSFDES
EDDLVAGGGGTSDPEDRSGSKPWKKLKTVLKYSPFVVSFHKHYYPWVQLSGHAGNFQAGE
DGRILKRFCQCEQRSLELLMGDPLRPFVPTYYGMVQRDGQAFNQMEDLLADFEGPSIMDC
KMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETLS
STSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDVGILRKYVARLEDLRDT
LENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWAEGNREDG
YLWGLDNLICLLQGLAQS

BDBM50040911

n/a

Name

BDBM50040911

Synonyms:

(+)-myo-inositol 1,4,5-trisphosphorothioate | (-)-chiro-inositol 1,4,6-trisphosphorothioate | 1,4,5-trisphosphate 5-phosphatase derivatives | Inositol 1,4,5-trisphosphorothioate | L-(1,4,5)PS3 | {[2,5-bis({[dioxido(sulfanylidene)--phosphanyl]oxy})-3,4,6-trihydroxycyclohexyl]oxy}(sulfanylidene)phosphonite

Type

Small organic molecule

Emp. Form.

C6H9O12P3S3

Mol. Mass.

462.248

SMILES

OC1C(O)C(OP([O-])([O-])=S)C(OP([O-])([O-])=S)C(O)C1OP([O-])([O-])=S

Structure