| Reaction Details |
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 | Report a problem with these data |
| Target | Thermolysin |
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| Ligand | BDBM50035235 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_210394 |
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| IC50 | 64±n/a nM |
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| Citation |  Bertenshaw, SR; Talley, JJ; Rogers, RS; Carter, JS; Moore, WM; Branson, LM; Koboldt, CM Thiol and hydroxamic acid containing inhibitors of endothelin converting enzyme Bioorg Med Chem Lett3:1953-1958 (1993) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thermolysin |
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| Name: | Thermolysin |
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| Synonyms: | THER_BACTH | npr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60097.54 |
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| Organism: | Bacillus thermoproteolyticus |
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| Description: | ChEMBL_1468794 |
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| Residue: | 548 |
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| Sequence: | MKMKMKLASFGLAAGLAAQVFLPYNALASTEHVTWNQQFQTPQFISGDLLKVNGTSPEEL
VYQYVEKNENKFKFHENAKDTLQLKEKKNDNLGFTFMRFQQTYKGIPVFGAVVTSHVKDG
TLTALSGTLIPNLDTKGSLKSGKKLSEKQARDIAEKDLVANVTKEVPEYEQGKDTEFVVY
VNGDEASLAYVVNLNFLTPEPGNWLYIIDAVDGKILNKFNQLDAAKPGDVKSITGTSTVG
VGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDA
PAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQ
TFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEI
GEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGG
THYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQ
AFDAVGVK
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| BDBM50035235 |
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| n/a |
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| Name | BDBM50035235 |
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| Synonyms: | CHEMBL2372437 | N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydroxy-2-isobutyl-malonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C12H22N4O5 |
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| Mol. Mass. | 302.3269 |
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| SMILES | CC(C)C[C@H](C(=O)NO)C(=O)N[C@@H](C)C(=O)NCC(N)=O |r| |
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| Structure | 
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