| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50284785 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40414 (CHEMBL652629) |
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| IC50 | >20000±n/a nM |
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| Citation |  Buynak, JD; Geng, B; Bachmann, B; Ling, Hua The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins Bioorg Med Chem Lett5:1513-1518 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_ENTCL | ampC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41306.67 |
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| Organism: | Enterobacter cloacae |
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| Description: | ChEMBL_40258 |
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| Residue: | 381 |
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| Sequence: | MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHY
YTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQ
WQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGA
LAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQA
YGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEA
NTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLA
NTSYPNPARVEAAYHILEALQ
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| BDBM50284785 |
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| n/a |
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| Name | BDBM50284785 |
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| Synonyms: | (6R,7Z)-3-[(acetyloxy)methyl]-7-(2-oxido-2-oxoethylidene)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; sodium salt | CHEMBL36888 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9NO7S |
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| Mol. Mass. | 311.268 |
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| SMILES | CC(=O)OCC1=C(N2[C@H](SC1)\C(=C/C([O-])=O)C2=O)C([O-])=O |t:5| |
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| Structure | 
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