Ki Summary

Reaction Details

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Target

Endothelin-1 receptor

Ligand

BDBM50032181

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_65804 (CHEMBL679707)

IC50

8±n/a nM

Citation

Neustadt, B; Wu, A; Smith, E; Nechuta, T; Fawzi, A; Zhang, H; Ganguly, A A case study of combinatorial libraries: Endothelin receptor antagonist hexapeptides Bioorg Med Chem Lett5:2041-2044 (1995) Article

More Info.:

Get all data from this article, Assay Method

Endothelin-1 receptor

Name:

Endothelin-1 receptor

Synonyms:

EDNRA | EDNRA_PIG | Endothelin receptor ET-A

Type:

PROTEIN

Mol. Mass.:

48707.29

Organism:

Sus scrofa

Description:

ChEMBL_65803

Residue:

427

Sequence:

METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN

BDBM50032181

n/a

Name

BDBM50032181

Synonyms:

2-{1-[1-(2-carboxy-1-{1-[10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl(methylcarboxamido)methylcarboxamido]-3-methylbutylcarboxamido}ethylcarboxamido)-2-methylbutylcarboxamido]-2-methylbutylcarboxamido}-3-(1H-3-indolyl)propanoic acid | 3-{2-[2-Acetylamino-2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-acetylamino]-4-methyl-pentanoylamino}-N-(1-{1-[1-carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-succinamic acid | CHEMBL262993

Type

Small organic molecule

Emp. Form.

C52H67N7O10

Mol. Mass.

950.1293

SMILES

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc12)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O

Structure