| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-1 receptor |
|---|
| Ligand | BDBM50285135 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_65797 (CHEMBL677978) |
|---|
| IC50 | 6±n/a nM |
|---|
| Citation |  Neustadt, B; Wu, A; Smith, E; Nechuta, T; Fawzi, A; Zhang, H; Ganguly, A A case study of combinatorial libraries: Endothelin receptor antagonist hexapeptides Bioorg Med Chem Lett5:2041-2044 (1995) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-1 receptor |
|---|
| Name: | Endothelin-1 receptor |
|---|
| Synonyms: | EDNRA | EDNRA_PIG | Endothelin receptor ET-A |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48707.29 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | ChEMBL_65803 |
|---|
| Residue: | 427 |
|---|
| Sequence: | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
|
|
|
|---|
| BDBM50285135 |
|---|
| n/a |
|---|
| Name | BDBM50285135 |
|---|
| Synonyms: | (S)-3-{(S)-2-[(R)-2-Acetylamino-2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-acetylamino]-propionylamino}-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-succinamic acid | CHEMBL433837 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C49H61N7O10 |
|---|
| Mol. Mass. | 908.0495 |
|---|
| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc12)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
