| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50285148 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_65803 |
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| IC50 | 5±n/a nM |
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| Citation |  Neustadt, B; Wu, A; Smith, E; Nechuta, T; Fawzi, A; Zhang, H; Ganguly, A A case study of combinatorial libraries: Endothelin receptor antagonist hexapeptides Bioorg Med Chem Lett5:2041-2044 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_PIG | Endothelin receptor ET-A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48707.29 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_65803 |
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| Residue: | 427 |
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| Sequence: | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
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| BDBM50285148 |
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| n/a |
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| Name | BDBM50285148 |
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| Synonyms: | 2-{1-[1-(2-carboxy-1-{1-[10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl(methylcarboxamido)methylcarboxamido]-3-methylbutylcarboxamido}ethylcarboxamido)-2-methylpropylcarboxamido]-2-methylbutylcarboxamido}-3-(1H-3-indolyl)propanoic acid | CHEMBL64271 |
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| Type | Small organic molecule |
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| Emp. Form. | C51H65N7O10 |
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| Mol. Mass. | 936.1027 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc12)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |
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| Structure | 
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