| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50286609 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_44154 (CHEMBL653305) |
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| IC50 | 23000±n/a nM |
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| Citation |  Coval, SJ; Conover, MA; Mierzwa, R; King, A; Puar, MS; Phife, DW; Pai, J; Burrier, RE; Ahn, H; Boykow, GC; Patel, M; Pomponi, SA Wiedendiol-A and -B, cholesteryl ester transfer protein inhibitors from the marine sponge Xestospongia wiedenmayeri Bioorg Med Chem Lett5:605-610 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50286609 |
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| n/a |
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| Name | BDBM50286609 |
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| Synonyms: | 1-((4aS,12bR)-9,10-Diacetyl-4,4,4a,12b-tetramethyl-1,3,4,4a,5,6,6a,9,12a,12b-decahydro-2H-benzo[a]xanthen-11-yl)-ethanone | CHEMBL347038 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H36O4 |
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| Mol. Mass. | 424.5723 |
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| SMILES | CC(=O)C1C=C2OC3CC[C@@]4(C)C(C)(C)CCC[C@]4(C)C3C=C2C(C(C)=O)=C1C(C)=O |c:23,29,t:4| |
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| Structure | 
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