| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
|---|
| Ligand | BDBM50291090 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_221310 |
|---|
| IC50 | 10000±n/a nM |
|---|
| Citation |  Myers, MR; Setzer, NN; Spada, A; Zulli, AL; Hsu, CJ; Zilberstein, A; Johnson, SE; Hook, LE; Jacoski, MV The preparation and sar of 4-(anilino), 4-(phenoxy), and 4-(thiophenoxy)-quinazolines: Inhibitors of p56lck and EGF-R tyrosine kinase activity Bioorg Med Chem Lett7:417-420 (1997) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Lck |
|---|
| Name: | Tyrosine-protein kinase Lck |
|---|
| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 57987.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06239 |
|---|
| Residue: | 509 |
|---|
| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
|
|
|
|---|
| BDBM50291090 |
|---|
| n/a |
|---|
| Name | BDBM50291090 |
|---|
| Synonyms: | (6,7-Dimethoxy-quinazolin-4-yl)-p-tolyl-amine; hydrochloride | CHEMBL1191611 | CHEMBL542733 | US10548897, Compound 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H17N3O3 |
|---|
| Mol. Mass. | 311.3352 |
|---|
| SMILES | COc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
