| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-converting enzyme 1 |
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| Ligand | BDBM21641 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_64201 |
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| IC50 | >100000±n/a nM |
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| Citation |  De Lombaert, S; Stamford, LB; Blanchard, L; Tan, J; Hoyer, D; Diefenbacher, CG; Wei, D; Wallace, EM; Moskal, MA; Savage, P; Jeng, AY Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11 Bioorg Med Chem Lett7:1059-1064 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-converting enzyme 1 |
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| Name: | Endothelin-converting enzyme 1 |
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| Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 87155.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42892 |
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| Residue: | 770 |
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| Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
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| BDBM21641 |
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| n/a |
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| Name | BDBM21641 |
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| Synonyms: | 2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CHEMBL10247 | Thiorphan |
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| Type | Small organic molecule |
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| Emp. Form. | C12H15NO3S |
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| Mol. Mass. | 253.317 |
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| SMILES | OC(=O)CNC(=O)C(CS)Cc1ccccc1 |
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| Structure | 
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