| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Papain |
|---|
| Ligand | BDBM50070497 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_152523 (CHEMBL757558) |
|---|
| IC50 | 105000±n/a nM |
|---|
| Citation |  Bajusz, S; Fauszt, I; Németh, K; Barabás, E; Juhász, A; Patthy, M Peptidyl beta-homo-aspartals: specific inhibitors of interleukin-1 beta converting enzyme and its homologues (caspases). Bioorg Med Chem Lett8:1477-82 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Papain |
|---|
| Name: | Papain |
|---|
| Synonyms: | Allergen=Car p 1 | PAPA1_CARPA | PPI | Papaya proteinase I |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 38923.01 |
|---|
| Organism: | Carica papaya |
|---|
| Description: | Papain was purchased from Sigma, Germany. |
|---|
| Residue: | 345 |
|---|
| Sequence: | MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYK
NIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTE
LSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNE
YSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKT
DGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYG
PNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
|
|
|
|---|
| BDBM50070497 |
|---|
| n/a |
|---|
| Name | BDBM50070497 |
|---|
| Synonyms: | CHEMBL37975 | {(S)-1-[(S)-4-Guanidino-1-(2-oxo-ethyl)-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid isobutyl ester |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H33N5O4 |
|---|
| Mol. Mass. | 419.5178 |
|---|
| SMILES | CC(C)COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)CC=O |
|---|
| Structure | 
|
|---|
Search and Browse
