| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA topoisomerase 2 |
|---|
| Ligand | BDBM50081426 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_208629 |
|---|
| IC50 | 132000±n/a nM |
|---|
| Citation |  Sato, S; Suga, Y; Yoshimura, T; Nakagawa, R; Tsuji, T; Umemura, K; Andoh, T Syntheses of novel antitumor dihydroxanthone derivatives with inhibitory activity against DNA topoisomerase II. Bioorg Med Chem Lett9:2653-6 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA topoisomerase 2 |
|---|
| Name: | DNA topoisomerase 2 |
|---|
| Synonyms: | DNA topoisomerase II | TOP2_DROME | Top2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 164413.06 |
|---|
| Organism: | Drosophila melanogaster |
|---|
| Description: | ChEMBL_208630 |
|---|
| Residue: | 1447 |
|---|
| Sequence: | MENGNKALSIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVP
GLYKIFDEILVNAADNKQRDKSMNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPT
MIFGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMG
KASDVQIKDFNGTDYTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAASSKGVSVFLNG
NKLGVRNFKDYIDLHIKNTDDDSGPPIKIVHEVANERWEVACCPSDRGFQQVSFVNSIAT
YKGGRHVDHVVDNLIKQLLEVLKKKNKGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKE
NMTLQQKGFGSKCTLSEKFINNMSKSGIVESVLAWAKFKAQNDIAKTGGRKSSKIKGIPK
LEDANEAGGKNSIKCTLILTEGDSAKSLAVSGLGVIGRDLYGVFPLRGKLLNVREANFKQ
LSENAEINNLCKIIGLQYKKKYLTEDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTN
WPELLRLPFLEEFITPIVKATKKNEELSFYSLPEFEEWKNDTANHHTYNIKYYKGLGTST
SKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKVWLTNHMDEVKRRKELGL
PERYLYTKGTKSITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFKRNDKR
EVKVAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRGQFGTRLSGGKDC
ASARYIFTIMSPLTRLIYHPLDDPLLDYQVDDGQKIEPLWYLPIIPMVLVNGAEGIGTGW
STKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSDGRYIQTGNIQILSGNR
LEISELPVGVWTQNYKENVLEPLSNGTEKVKGIISEYREYHTDTTVRFVISFAPGEFERI
HAEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFLV
GQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMED
AEQADEEDEEEEEAAPSVSSKAKKEKEVDPEKAFKKLTDVKKFDYLLGMSMWMLTEEKKN
ELLKQRDTKLSELESLRKKTPEMLWLDDLDALESKLNEVEEKERAEEQGINLKTAKALKG
QKSASAKGRKVKSMGGGAGAGDVFPDPDGEPVEFKITEEIIKKMAAAAKVAQAAKEPKKP
KEPKEPKVKKEPKGKQIKAEPDASGDEVDEFDAMVEGGSKTSPKAKKAVVKKEPGEKKPR
QKKENGGGLKQSKIDFSKAKAKKSDDDVEEVTPRAERPGRRQASKKIDYSSLFSDEEEDG
GNVGSDDDGNASDDDSPKRPAKRGREDESSGGAKKKAPPKKRRAVIESDDDDIEIDEDDD
DDSDFNC
|
|
|
|---|
| BDBM50081426 |
|---|
| n/a |
|---|
| Name | BDBM50081426 |
|---|
| Synonyms: | (4R,4aS)-4,8-Dihydroxy-6-methyl-9-oxo-4,9-dihydro-xanthene-4a-carboxylic acid methylamide | CHEMBL92495 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H15NO5 |
|---|
| Mol. Mass. | 301.294 |
|---|
| SMILES | CNC(=O)[C@]12Oc3cc(C)cc(O)c3C(=O)C1=CC=C[C@H]2O |c:18,20| |
|---|
| Structure | 
|
|---|
Search and Browse
