| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50092268 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_40417 |
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| IC50 | 43000±n/a nM |
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| Citation |  Grant, EB; Guiadeen, D; Baum, EZ; Foleno, BD; Jin, H; Montenegro, DA; Nelson, EA; Bush, K; Hlasta, DJ The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors. Bioorg Med Chem Lett10:2179-82 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_ENTCL | ampC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41306.67 |
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| Organism: | Enterobacter cloacae |
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| Description: | ChEMBL_40258 |
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| Residue: | 381 |
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| Sequence: | MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHY
YTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQ
WQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGA
LAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQA
YGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEA
NTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLA
NTSYPNPARVEAAYHILEALQ
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| BDBM50092268 |
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| n/a |
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| Name | BDBM50092268 |
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| Synonyms: | 5-(4-nitrobenzylidene)-2-thioxothiazolidin-4-one | 5-[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one | CHEMBL66064 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H6N2O3S2 |
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| Mol. Mass. | 266.296 |
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| SMILES | [O-][N+](=O)c1ccc(C=C2SC(S)=NC2=O)cc1 |w:7.6,c:11| |
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| Structure | 
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