| Reaction Details |
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 | Report a problem with these data |
| Target | 72 kDa type IV collagenase |
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| Ligand | BDBM50095222 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_104386 |
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| IC50 | 1.3±n/a nM |
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| Citation |  Barta, TE; Becker, DP; Bedell, LJ; De Crescenzo, GA; McDonald, JJ; Munie, GE; Rao, S; Shieh, HS; Stegeman, R; Stevens, AM; Villamil, CI Synthesis and activity of selective MMP inhibitors with an aryl backbone. Bioorg Med Chem Lett10:2815-7 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 72 kDa type IV collagenase |
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| Name: | 72 kDa type IV collagenase |
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| Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 73870.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08253 |
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| Residue: | 660 |
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| Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
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| BDBM50095222 |
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| n/a |
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| Name | BDBM50095222 |
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| Synonyms: | CHEMBL83209 | N-Hydroxy-2-[4-(4-trifluoromethyl-phenoxy)-piperidine-1-sulfonyl]-benzamide | N-hydroxy-2-(4-(4-(trifluoromethyl)phenoxy)piperidin-1-ylsulfonyl)benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19F3N2O5S |
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| Mol. Mass. | 444.425 |
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| SMILES | ONC(=O)c1ccccc1S(=O)(=O)N1CCC(CC1)Oc1ccc(cc1)C(F)(F)F |
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| Structure | 
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