| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Progesterone receptor |
|---|
| Ligand | BDBM50086551 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_159080 (CHEMBL763212) |
|---|
| EC50 | 2290±n/a nM |
|---|
| Citation |  Zhi, L; Tegley, CM; Pio, B; West, SJ; Marschke, KB; Mais, DE; Jones, TK Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines. Bioorg Med Chem Lett10:415-8 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Progesterone receptor |
|---|
| Name: | Progesterone receptor |
|---|
| Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 98979.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06401 |
|---|
| Residue: | 933 |
|---|
| Sequence: | MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
|
|
|
|---|
| BDBM50086551 |
|---|
| n/a |
|---|
| Name | BDBM50086551 |
|---|
| Synonyms: | 4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-quinolin-6-yl)-thiophene-2-carbonitrile | CHEMBL134260 | racemic-4-methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carbonitrile |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H20N2S |
|---|
| Mol. Mass. | 296.43 |
|---|
| SMILES | CC1CC(C)(C)Nc2ccc(cc12)-c1sc(cc1C)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
