Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetFructose-1,6-bisphosphatase 1 (FBPase)
LigandBDBM3556
Substrate/Competitorn/a
Meas. Tech.ChEBML_86713
IC50 1700±n/a nM
Citation Wright SWHageman DLMcClure LDCarlo AATreadway JLMathiowetz AMWithka JMBauer PH Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines. Bioorg Med Chem Lett 11:17-21 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Fructose-1,6-bisphosphatase 1 (FBPase)
Name:Fructose-1,6-bisphosphatase
Synonyms:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1
Type:Protein
Mol. Mass.:36843.58
Organism:Homo sapiens (Human)
Description:Liver FBPase (P09467)
Residue:338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM3556
n/a
NameBDBM3556
Synonyms:4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline | CHEMBL1204199 | CHEMBL35820 | N-(3-bromophenyl)-6,7-diethoxyquinazolin-4-amine | PD153035 Analog | PD153035 Analog 56
TypeSmall organic molecule
Emp. Form.C18H18BrN3O2
Mol. Mass.388.258
SMILESCCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCC
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: