| Reaction Details |
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 | Report a problem with these data |
| Target | Collagenase 3 |
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| Ligand | BDBM50096476 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_106638 |
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| IC50 | 233±n/a nM |
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| Citation |  Levin, JI; Gu, Y; Nelson, FC; Zask, A; DiJoseph, JF; Sharr, MA; Sung, A; Jin, G; Cowling, R; Chanda, P; Cosmi, S; Hsiao, CL; Edris, W; Wilhelm, J; Killar, LM; Skotnicki, JS Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett11:239-42 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Collagenase 3 |
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| Name: | Collagenase 3 |
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| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53808.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P45452 |
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| Residue: | 471 |
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| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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| BDBM50096476 |
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| n/a |
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| Name | BDBM50096476 |
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| Synonyms: | (R)-2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-cyclohexanecarboxylic acid hydroxyamide | CHEMBL81113 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26N2O5S |
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| Mol. Mass. | 418.507 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C1CCCC[C@H]1C(=O)NO |
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| Structure | 
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