| Reaction Details |
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 | Report a problem with these data |
| Target | Neuraminidase |
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| Ligand | BDBM50097659 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_200653 |
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| IC50 | 100±n/a nM |
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| Citation |  Wyatt, PG; Coomber, BA; Evans, DN; Jack, TI; Fulton, HE; Wonacott, AJ; Colman, P; Varghese, J Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides. Bioorg Med Chem Lett11:669-73 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuraminidase |
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| Name: | Neuraminidase |
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| Synonyms: | Influenza B Virus Neuraminidase | NA | NRAM_INBLE | Neuraminidase | Neuraminidase B |
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| Type: | Enzyme |
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| Mol. Mass.: | 51446.67 |
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| Organism: | Influenza B virus (B/Lee/40) |
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| Description: | n/a |
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| Residue: | 466 |
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| Sequence: | MLPSTVQTLTLLLTSGGVLLSLYVSASLSYLLYSDVLLKFSSTKTTAPTMSLECTNASNA
QTVNHSATKEMTFPPPEPEWTYPRLSCQGSTFQKALLISPHRFGEIKGNSAPLIIREPFV
ACGPKECRHFALTHYAAQPGGYYNGTRKDRNKLRHLVSVKLGKIPTVENSIFHMAAWSGS
ACHDGREWTYIGVDGPDNDALVKIKYGEAYTDTYHSYAHNILRTQESACNCIGGDCYLMI
TDGSASGISKCRFLKIREGRIIKEILPTGRVEHTEECTCGFASNKTIECACRDNSYTAKR
PFVKLNVETDTAEIRLMCTKTYLDTPRPDDGSIAGPCESNGDKWLGGIKGGFVHQRMASK
IGRWYSRTMSKTNRMGMELYVKYDGDPWTDSDALTLSGVMVSIEEPGWYSFGFEIKDKKC
DVPCIGIEMVHDGGKDTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
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| BDBM50097659 |
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| n/a |
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| Name | BDBM50097659 |
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| Synonyms: | (4S,5R,6R)-4-Amino-6-(phenethyl-propyl-carbamoyl)-5-(2,2,2-trifluoro-acetylamino)-5,6-dihydro-4H-pyran-2-carboxylic acid | CHEMBL348066 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24F3N3O5 |
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| Mol. Mass. | 443.4169 |
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| SMILES | CCCN(CCc1ccccc1)C(=O)[C@@H]1OC(=C[C@H](N)[C@H]1NC(=O)C(F)(F)F)C(O)=O |c:17| |
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| Structure | 
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