| Reaction Details |
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 | Report a problem with these data |
| Target | Neuraminidase |
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| Ligand | BDBM50097649 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_200639 |
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| IC50 | 17±n/a nM |
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| Citation |  Wyatt, PG; Coomber, BA; Evans, DN; Jack, TI; Fulton, HE; Wonacott, AJ; Colman, P; Varghese, J Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides. Bioorg Med Chem Lett11:669-73 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuraminidase |
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| Name: | Neuraminidase |
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| Synonyms: | Influenza A Virus Neuraminidase | NA | NRAM_I34A1 | Neuraminidase | Neuraminidase A |
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| Type: | Enzyme |
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| Mol. Mass.: | 50124.14 |
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| Organism: | Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(H1N1)) |
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| Description: | P03468 |
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| Residue: | 454 |
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| Sequence: | MNPNQKIITIGSICLVVGLISLILQIGNIISIWISHSIQTGSQNHTGICNQNIITYKNST
WVKDTTSVILTGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLT
QGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGI
SGPDNGAVAVLKYNGIITETIKSWRKKILRTQESECACVNGSCFTIMTDGPSDGLASYKI
FKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIG
YICSGVFGDNPRPEDGTGSCGPVYVDGANGVKGFSYRYGNGVWIGRTKSHSSRHGFEMIW
DPNGWTETDSKFSVRQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPKEKT
IWTSASSISFCGVNSDTVDWSWPDGAELPFSIDK
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| BDBM50097649 |
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| n/a |
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| Name | BDBM50097649 |
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| Synonyms: | (4R,5R,6R)-5-Acetylamino-4-hydroxy-6-(phenethyl-propyl-carbamoyl)-5,6-dihydro-4H-pyran-2-carboxylic acid | CHEMBL350837 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N2O6 |
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| Mol. Mass. | 390.4302 |
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| SMILES | CCCN(CCc1ccccc1)C(=O)[C@@H]1OC(=C[C@@H](O)[C@H]1NC(C)=O)C(O)=O |c:17| |
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| Structure | 
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