Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50120148 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_145476 |
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Ki | 9372±n/a nM |
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Citation | Wu, WL; Caplen, MA; Domalski, MS; Zhang, H; Fawzi, A; Burnett, DA Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands. Bioorg Med Chem Lett12:3157-60 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50120148 |
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n/a |
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Name | BDBM50120148 |
Synonyms: | C-((S)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3,5-difluoro-phenyl)-pentyl]-azetidin-2-yl})-methylamine | CHEMBL324895 |
Type | Small organic molecule |
Emp. Form. | C21H25ClF2N2 |
Mol. Mass. | 378.886 |
SMILES | CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1cc(F)cc(F)c1 |
Structure |
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