| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingomyelin phosphodiesterase 2 |
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| Ligand | BDBM50100341 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_144315 |
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| IC50 | 1000±n/a nM |
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| Citation |  Taguchi, M; Sugimoto, K; Goda, K; Akama, T; Yamamoto, K; Suzuki, T; Tomishima, Y; Nishiguchi, M; Arai, K; Takahashi, K; Kobori, T Sphingomyelin analogues as inhibitors of sphingomyelinase. Bioorg Med Chem Lett13:1963-6 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingomyelin phosphodiesterase 2 |
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| Name: | Sphingomyelin phosphodiesterase 2 |
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| Synonyms: | NSMA_RAT | Neutral sphingomyelinase | Smpd2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47651.22 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_611790 |
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| Residue: | 422 |
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| Sequence: | MKHNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLESFDLALLEEVWSEQDFQYLK
QKLSLTYPDAHYFRSGIIGSGLCVFSRHPIQEIVQHVYTLNGYPYKFYHGDWFCGKAVGL
LVLHLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKKANVVLLCGDLN
MHPKDLGCCLLKEWTGLRDAFVETEDFKGSEDGCTMVPKNCYVSQQDLGPFPFGVRIDYV
LYKAVSGFHICCKTLKTTTGCDPHNGTPFSDHEALMATLCVKHSPPQEDPCSAHGSAERS
ALISALREARTELGRGIAQARWWAALFGYVMILGLSLLVLLCVLAAGEEAREVAIMLWTP
SVGLVLGAGAVYLFHKQEAKSLCRAQAEIQHVLTRTTETQDLGSEPHPTHCRQQEADRAE
EK
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| BDBM50100341 |
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| n/a |
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| Name | BDBM50100341 |
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| Synonyms: | (2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl-hexadeca-2,4,6,12-tetraenoic acid [(S)-1-hydroxymethyl-2-((1S,2S,6S)-2-hydroxy-3-oxo-7-oxa-bicyclo[4.1.0]hept-4-en-2-yl)-ethyl]-amide | CHEMBL418376 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H43NO5 |
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| Mol. Mass. | 485.6554 |
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| SMILES | CC[C@@H](C)\C=C(/C)C[C@@H](C)C[C@@H](C)\C=C\C=C\C=C\C(=O)N[C@H](CO)C[C@]1(O)[C@H]2O[C@H]2C=CC1=O |c:32| |
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| Structure | 
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