| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM50130063 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_48979 |
|---|
| IC50 | 27±n/a nM |
|---|
| Citation |  South, MS; Dice, TA; Girard, TJ; Lachance, RM; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; Parlow, JJ Polymer-assisted solution-phase (PASP) parallel synthesis of an alpha-ketothiazole library as tissue factor VIIa inhibitors. Bioorg Med Chem Lett13:2363-7 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54726.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
|---|
| BDBM50130063 |
|---|
| n/a |
|---|
| Name | BDBM50130063 |
|---|
| Synonyms: | (R)-N-{(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-phenyl-ethyl}-3-phenyl-2-phenylmethanesulfonylamino-propionamide | (R)-N-{1-[(S)-(S)-4-Guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-phenyl-ethyl}-3-phenyl-2-phenylmethanesulfonylamino-propionamide | CHEMBL78055 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H39N7O5S2 |
|---|
| Mol. Mass. | 689.847 |
|---|
| SMILES | NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)Cc1ccccc1)C(=O)c1nccs1 |
|---|
| Structure | 
|
|---|
Search and Browse
