| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM18046 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54392 (CHEMBL668776) |
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| IC50 | 310±n/a nM |
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| Citation |  Zolli-Juran, M; Cechetto, JD; Hartlen, R; Daigle, DM; Brown, ED High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate. Bioorg Med Chem Lett13:2493-6 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
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| Type: | n/a |
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| Mol. Mass.: | 17532.46 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 157 |
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| Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
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| BDBM18046 |
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| n/a |
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| Name | BDBM18046 |
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| Synonyms: | 5-((4-methylphenyl)thio)-quinazoline 2,4-diamine, 1 | 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE | 5-[(4-methylphenyl)sulfanyl]quinazoline-2,4-diamine | 5-[(4-methylphenyl)sulfanyl]quinazoline-2,4-diamine, 2c | CHEMBL83547 | GW578 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14N4S |
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| Mol. Mass. | 282.363 |
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| SMILES | Cc1ccc(Sc2cccc3nc(N)nc(N)c23)cc1 |
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| Structure | 
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