Reaction Details |
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Target | Tissue-type plasminogen activator |
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Ligand | BDBM50131458 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_207888 |
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Ki | 480±n/a nM |
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Citation | Nantermet, PG; Barrow, JC; Newton, CL; Pellicore, JM; Young, M; Lewis, SD; Lucas, BJ; Krueger, JA; McMasters, DR; Yan, Y; Kuo, LC; Vacca, JP; Selnick, HG Design and synthesis of potent and selective macrocyclic thrombin inhibitors. Bioorg Med Chem Lett13:2781-4 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tissue-type plasminogen activator |
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Name: | Tissue-type plasminogen activator |
Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
Type: | Enzyme |
Mol. Mass.: | 62931.08 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 562 |
Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
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BDBM50131458 |
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n/a |
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Name | BDBM50131458 |
Synonyms: | (14E,21S)-21-benzyl-8,26-dichloro-12,17-dioxa-1,4,19,22,24-pentaazatricyclo[21.3.1.0^{6,11}]heptacosa-6(11),7,9,14,23,25-hexaene-3,18,27-trione | CHEMBL94864 |
Type | Small organic molecule |
Emp. Form. | C27H27Cl2N5O5 |
Mol. Mass. | 572.44 |
SMILES | Clc1ccc2OC\C=C\COC(=O)NC[C@H](Cc3ccccc3)Nc3ncc(Cl)n(CC(=O)NCc2c1)c3=O |t:7| |
Structure |
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