| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50136520 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106183 (CHEMBL714602) |
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| EC50 | >5000±n/a nM |
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| Citation |  Ujjainwalla, F; Warner, D; Walsh, TF; Wyvratt, MJ; Zhou, C; Yang, L; Kalyani, RN; MacNeil, T; Van der Ploeg, LH; Rosenblum, CI; Tang, R; Vongs, A; Weinberg, DH; Goulet, MT Design and syntheses of melanocortin subtype-4 receptor agonists: evolution of the pyridazinone archetype. Bioorg Med Chem Lett13:4431-5 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50136520 |
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| n/a |
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| Name | BDBM50136520 |
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| Synonyms: | (3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-2-methyl-propyl}-amide; hydrochloride | CHEMBL555316 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H35ClN4O3S |
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| Mol. Mass. | 603.174 |
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| SMILES | COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC(C)CNC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O |
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| Structure | 
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