| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1B |
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| Ligand | BDBM50145338 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1343 |
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| Ki | >1000±n/a nM |
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| Citation |  Timms, GH; Boot, JR; Broadmore, RJ; Carney, SL; Cooper, J; Findlay, JD; Gilmore, J; Mitchell, S; Moore, NA; Pullar, I; Sanger, GJ; Tomlinson, R; Tree, BB; Wedley, S SAR development of a selective 5-HT1D antagonist/serotonin reuptake inhibitor lead using rapid parallel synthesis. Bioorg Med Chem Lett14:2469-72 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1B |
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| Name: | 5-hydroxytryptamine receptor 1B |
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| Synonyms: | 5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 43579.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells |
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| Residue: | 390 |
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| Sequence: | MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT
LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV
VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI
SLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL
KQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLE
KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL
NSLINPIIYTMSNEDFKQAFHKLIRFKCTS
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| BDBM50145338 |
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| n/a |
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| Name | BDBM50145338 |
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| Synonyms: | 1-{2-[(S)-4-(6-Fluoro-1H-indol-3-yl)-2-methyl-piperidin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide | CHEMBL311787 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30FN3O2 |
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| Mol. Mass. | 435.5337 |
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| SMILES | C[C@H]1CC(CCN1CCC1OCCc2cc(ccc12)C(N)=O)c1c[nH]c2cc(F)ccc12 |
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| Structure | 
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